People who settled in this country in the late 1700's, especially those in the southeast, found native grape vines that came to be known as muscadines. In the wild, muscadines tend to grow aggressively and grow very long runners. However, they don't typically produce much fruit. It is possible to regularly have fruit if it has fewer vines. There are a few ways to help you achieve this with your own vines.
First, build a wire trellis. Take one of the best branches of the vine and grow it out on the trellis wire. Another good branch can grow up. Then you'll want to cut off any side branches, even if they have muscadines growing on them. It will depend on the main trunk lines of the branches to take care of the load. Three to six main branches can each supply several pounds of muscadines every year if you keep pruning back the other vines and keep only the spurs that will develop on the main branches.