The wreck happened just before midnight Sunday. Police say an 18-wheeler and a Subaru collided just north of I-565 on Memorial Parkway.
The Subaru was flipped on its side blocking the Parkway.
Huntsville Fire and HEMSI Paramedics responded. Both drivers were taken to Huntsville Hospital with minor injuries.
The Parkway was reopened within a half hour.
It is not clear why the two vehicles collided.