The wreck happened just before midnight Tuesday at the intersection of Wynn and Bradford Drives.
Huntsville police say two cars collided in the intersection. One of the vehicles rammed into the side of the other, sending that vehicle into the Redstone Federal Credit Union sign.
HEMSI sent four ambulances to the crash. Three adults and two children were taken to Huntsville Hospital. Their injuries were not life threatening.
Police had to block off the intersection for more than an hour to investigate and for crews to clean up the wreckage.